The Mutating SARS-CoV-2 Is Gaining Virulence Against the Young COVID-19 Patients

SWITZERLAND, THURSDAY, 7 MAY 2020 10:00 PM CET

As the world’s first AI-biopharma company that has discovered and publicized the precise aetiology and pathology of COVID-19¹, we are committed to the non-profit dissemination of our COVID-19 discoveries and the public validation of our COVID-19 clinical predictions.

We have conducted comprehensive functional analyses of the diverse mutations of more than 4000 SARS-CoV-2 viral isolates available at GISAID² and other public sources^3,4. We hereby present the following pathology-based clinical predictions that the diverse mutations converge upon increasing infectivity of SARS-CoV-2 and increasing severity of COVID-19:

The diverse mutations of the SARS-CoV-2 genome have enhanced both viral replication and viral spread consistent with the unbiased survival strategy of SARS-CoV-2¹. In particular, the mutated SARS-CoV-2 strains could exert a more potent suppression of both the innate and the adaptive antiviral immune response upon their successful entry into host cells, resulting in a further increase in the peak viral load and a further delay of the first symptom onset.

Furthermore, the diverse mutations of the SARS-CoV-2 genome have enhanced the differential hematologic complications in young and elderly patients^5,6. In particular, the mutated SARS-CoV-2 strains could increasingly cause hematologic adaptive hyperinflammation in young COVID-19 patients at the early stage of disease progression, resulting in severe complications such as thrombophilia and necrotizing vasculitis. In contrast, the mutated SARS-CoV-2 strains could increasingly cause hematologic innate hyperinflammation in elderly COVID-19 patients at the late stage of disease progression, resulting in severe complications such as purpura.

In summary, we predict that the diverse mutations of SARS-CoV-2 converge upon compensatory mechanisms that lead to longer viral sheddings, higher peak viral loads, worse clinical progressions, severer hematological complications, faster mutation rates, accelerated host aging, and more persistent infections.

As young and elderly populations are increasingly vulnerable to mutated SARS-CoV-2 strains, protective measures such as social distancing and online classrooms should not be relaxed.

The rational discovery of unbiased COVID-19 treatments and vaccines that target the exact mechanisms for both viral replication and host immunomodulation reinforced by SARS-CoV-2 mutations may be the only effective means to put an end to the COVID-19 pandemic.

 REFERENCES

1. Lovetrue, B. The AI-Discovered Aetiology of COVID-19 and Rationale of the Irinotecan+Etoposide Combination Therapy for Critically Ill COVID-19 Patients. (2020). doi:10.20944/PREPRINTS202003.0341.V1

2. Elbe, S. & Buckland-Merrett, G. Data, disease and diplomacy: GISAID’s innovative contribution to global health. Glob. Challenges 1, 33–46 (2017).

3. Yao, H. et al. Patient-derived mutations impact pathogenicity of SARS-CoV-2. medRxiv 2020.04.14.20060160 (2020). doi:10.1101/2020.04.14.20060160

4. Su, Y. C. F. et al. Discovery of a 382-nt deletion during the early evolution of SARS-CoV-2. bioRxiv 2020.03.11.987222 (2020). doi:10.1101/2020.03.11.987222

5. Zulfiqar, A.-A., Lorenzo-Villalba, N., Hassler, P. & Andrès, E. Immune Thrombocytopenic Purpura in a Patient with Covid-19. N. Engl. J. Med. 43, e43 (2020).

6. Bowles, L. et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N. Engl. J. Med. (2020). doi:10.1056/NEJMc2013656

About Demiurge Technologies AG

Demiurge Technologies is a research-based AI-biopharmaceutical company that transforms publicly available life science data into precise disease models in areas with unmet medical needs. The company pioneers a self-correcting scientific approach that validates disease models with the accuracy of AI-based predictions of phase 3 clinical trial outcomes. The company also pioneers a self-sustaining business that commercializes disease models by accelerating the AI-based discovery and development of innovative medicines. Demiurge started in 2016 with headquarters in Switzerland.

AI has been an emerging powerful approach to deeper disease understanding and faster drug discovery, yet it must be put to the most rigorous test to prove its worth under public scrutiny. Demiurge has predicted the outcomes of more than 90 phase 3 clinical trials across multiple therapeutic areas and achieved more than 80% accuracy. Furthermore, we have been inviting the public to witness our future predictions of clinical trial outcomes on Twitter (@DemiurgeTech).

Therefore, we officially put forward AI-based discoveries of the complete aetiology and pathology of COVID-19 and the candidate treatments for COVID-19 as scientific hypotheses only and invite the world to validate their potential to solve the unprecedented global crisis posed by COVID-19.

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